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Table 2 In vivo response to hormonal stimuli in patients with AIMAH

From: ACTH-independent macronodular adrenocortical hyperplasia reveals prevalent aberrant in vivo and in vitroresponses to hormonal stimuli and coupling of arginine-vasopressin type 1a receptor to 11β-hydroxylase

Stimulus n tested Partial response (25-50%) n (%) Full response ≥50%) n (%)
ACTH1-24 29 - 28 (97%)
Posture 26 4 (15%) 13 (50%)
Salt loading 6 1 (17%) 1 (17%)
AVP 21 6 (29%) 12 (52%)
Metoclopramide 29 3 (10%) 7 (24%)
LHRH 30 5 (17%) 5 (17%)
TRH 29 2 (7 %) 3 (10%)
Glucagon 26 4 (15%) 4 (15%)
Mixed meal 32 2 (6%) 6 (18%)
Number of aberrant responses n n
0   20 8
1   8 10
2   4 11
3   3 5
4   0 1