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Table 2 In vivo response to hormonal stimuli in patients with AIMAH

From: ACTH-independent macronodular adrenocortical hyperplasia reveals prevalent aberrant in vivo and in vitroresponses to hormonal stimuli and coupling of arginine-vasopressin type 1a receptor to 11β-hydroxylase

Stimulus

n tested

Partial response (25-50%) n (%)

Full response ≥50%) n (%)

ACTH1-24

29

-

28 (97%)

Posture

26

4 (15%)

13 (50%)

Salt loading

6

1 (17%)

1 (17%)

AVP

21

6 (29%)

12 (52%)

Metoclopramide

29

3 (10%)

7 (24%)

LHRH

30

5 (17%)

5 (17%)

TRH

29

2 (7 %)

3 (10%)

Glucagon

26

4 (15%)

4 (15%)

Mixed meal

32

2 (6%)

6 (18%)

Number of aberrant responses

n

n

0

 

20

8

1

 

8

10

2

 

4

11

3

 

3

5

4

 

0

1