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Table 1 Characteristics of AIMAH patients evaluated in vivo

From: ACTH-independent macronodular adrenocortical hyperplasia reveals prevalent aberrant in vivo and in vitroresponses to hormonal stimuli and coupling of arginine-vasopressin type 1a receptor to 11β-hydroxylase

Total 35
Male/female 9/26
Age (years) 56.1±9.8
Adrenalectomy 22 (63%)
Hypercortisolism  
  - SCS 13 (37%)
  - CCS 22 (63%)
Diameter adrenal (mm)  
  - left SCS 31.7±10.1
  - left CCS 46.1±16.9*
  - right SCS 27.2±8.8
  - right CCS 43.6±17.0*
Hypertension  
  - SCS 7 (54%)
  - CCS 17 (77%)
Diabetes mellitus  
  - SCS 6 (46%)
  - CCS 6 (29%)
Bone loss  
  - Osteopenia  
   • SCS 4 (31%)
   • CCS 4 (18%)
  - Osteoporosis  
   • SCS 5 (42%)
   • CCS 5 (24%)
Midnight cortisol (nmol/l)  
  - SCS 184±80
  - CCS 319±145*
Urinary free cortisol (nmol/24h)  
  - SCS 481±121 (0% > URL)
  - CCS 1048±197* (37% > URL)
Cortisol after dexamethasone (nmol/l)  
  - SCS 145±131 (92% > URL)
  - CCS 296±183* (95% > URL)
ACTH (pmol/l)  
  - SCS 1.47±0.92 (39% nd)
  - CCS 0.85±0.89 (85% nd)
  1. SCS: subclinical Cushing’s syndrome, CCS: clinical Cushing’s syndrome, URL: upper reference limit, nd: non-detectable, data presented as mean±SD, *P<0.05, compared to SCS. ACTH levels below the lower detection limit of 1.10 pmol/l were set at 0.55 pmol/l.