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Figure 3 | Orphanet Journal of Rare Diseases

Figure 3

From: ACTH-independent macronodular adrenocortical hyperplasia reveals prevalent aberrant in vivo and in vitroresponses to hormonal stimuli and coupling of arginine-vasopressin type 1a receptor to 11β-hydroxylase

Figure 3

AVP receptor expression in adrenal tissues. (A) AVP type 1a receptor (V1, AVPR1A) mRNA expression in human adrenocortical tissues (Nl: normal, Hyp: ACTH-dependent hyperplasia, ADA: adrenocortical adenoma, ACC: adrenocortical carcinoma), measured by qRT-PCR. R.U.: relative units, compared to HPRT1 expression. *p<0.05, Kruskal-Wallis test. V2 and V3 receptor expression levels were extremely low or undetectable. (B) Significant correlation between AVPR1A expression levels and the induction of CYP11B1 by 100 nM AVP after 48 hours in cultures of primary cells of adrenal tissues. Corresponding icons for individual tissue groups are depicted in Figure A and B.

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Orphanet Journal of Rare Diseases

ISSN: 1750-1172