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I. main criteria
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Primary sterile pustule or ulcer with livid, undermined wound-border[1, 14, 15, 18–21]
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Exclusion of other relevant differential diagnoses like chronic venous/arterial leg ulcer, pyodermatitis, vasculitis[1, 14, 15, 18–20]
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II. additional criteria
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Histology of the wound-border: neutrophilic infiltration of the dermis with signs of vasculitis and accumulation of immunglobulins and/or complement factors beside the vessels[14, 15, 20]
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Existence of relevant, associated concomitant diseases like chronic inflammatory bowel diseases, arthropathies, haematological disorders, neoplasia, endocrine dysfunctions, metabolic syndrome[14, 15]
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Response to a systemic immunosuppressive therapy or no response to a conventional ulcer-therapy[15, 20]
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Triggering of a PG by pathergy-phenomenon[14, 15, 20]
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Extremely painful ulcer (VAS > 4 points)[14, 15]
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