Table 1 Modified diagnostic criteria for PG[1, 18–23]
I. main criteria | Primary sterile pustule or ulcer with livid, undermined wound-border[1, 14, 15, 18–21] |
Exclusion of other relevant differential diagnoses like chronic venous/arterial leg ulcer, pyodermatitis, vasculitis[1, 14, 15, 18–20] | |
II. additional criteria | Histology of the wound-border: neutrophilic infiltration of the dermis with signs of vasculitis and accumulation of immunglobulins and/or complement factors beside the vessels[14, 15, 20] |
Existence of relevant, associated concomitant diseases like chronic inflammatory bowel diseases, arthropathies, haematological disorders, neoplasia, endocrine dysfunctions, metabolic syndrome[14, 15] | |
Response to a systemic immunosuppressive therapy or no response to a conventional ulcer-therapy[15, 20] | |