Table 1 The incidence of virally induced cholestasis and biliary atresia depends on three variable parameters, mouse strain, time (hours post partum) and dosage of Rhesus rotavirus application
Variable parameter | Cholestasis | Biliary atresia |
|---|---|---|
Mouse strain | ||
Balb/c 55, 71 | 67%-85% | 67%-91% |
CD 59 | 33% | 46% |
NMRI 59 | 19% | 50% |
C57Bl6 67 | 13% | 100% |
Balb/c-IFN-γ–/–65 | 90%-100% | 20% |
Balb/c-TNF-α–/–68 | No data | 86% |
Balb/c-Mx + −A2G 71 | 65% | 65% |
WT 129 70 | 30% | 50% |
A 129 IFN-α/β receptor–/–70 | 79% | 96% |
G 129 IFN-γ receptor–/–70 | 39% | 86% |
AG 129 IFN-α/β/ γ receptor–/–70 | 70% | 96% |
Age at infection | ||
12-24Â hours 65, 83 | 80%-86% | 90%-100% |
24-48Â hours 55 | 61%-85% | 69%-91% |
48-72Â hours 52, 53 | 13%-42% | 0-17% |
Infective dose | ||
107* pfu 62 | 100% | 100% |
106 pfu 62 | 86% | 100% |
105 pfu 62 | 38% | 100% |
104 pfu 62 | 0 | 0 |