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Table 1 Baseline data of the 23 children with hypersensitivity pneumonitis included into the study

From: Hypersensitivity pneumonitis: lessons for diagnosis and treatment of a rare entity in children

Sex

9 male of 23 total

Age at 1st visit (y)

9.8 ± 3

Time to diagnosis (mon)

1.3 ± 1

   Initial presentation

 

Chronic cough, dyspnoea at rest, cyanosis, clubbing

15, 13, 11, 3 of 23

Loss of weight per week until diagnosis (kg)

- 0.73 ± 0.49

Non-pulmonary diagnoses

Atopic eczema (2), Diabetes mellitus Type I (1), hyperthyreoiditis, adipositas (4), house dust mite allergy (2), bronchial asthma (1), celiac disease (2), small stature (1), hypothyroidism (1), alopecia areata (1), enuresis nocturna (1), vitiligo (1), GERD and nissen fundoplication (1)

   Serum measurements

 

Elevated fungus IgG

17 of 23

Elevated bird IgG

21 of 23

Total IgG (fold upper limit)

1.2 ± 0.6

LDH i. S. (U/l)

352 ± 189

ACE i. S.(U/l)

53 ± 31

Positive serology for mycoplasma

9 of 17 assessed

  Bronchoalveolar lavage measurements

Done in 17 children

Total cell count (/μl)

8800 ± 11017

Macrophages (%)

41 ± 25

Lymphocytes (%)

46 ± 26

Neutrophils (%)

13 ± 13

Eosinophils (%)

2.6 ± 2.1

CD4+/CD8+ (% Lymph)

36 ± 16/48 ± 25

CD4/CD8 Ratio

2.0 ± 2.8

Cultured bacteria

None

Mycoplasma/Chlamydia

7 negative of 7 assessed for PCR in BAL

   Lung function measurement

Done in 22 children

FEV1 (% pred)

44 ± 21

FVC (% pred)

38 ± 15

MEF25 (% pred)

62 ± 45

DLCOcHb (% pred)

52 ± 28

SaO2 (%) Rest/excercise

93 ± 27/83 ± 40

pO2 (mmHg) Rest/excercise

64 ± 34/57 ± 20

pCO2 (mmHg) Rest/excercise

38 ± 20/34 ± 12

   Lung biopsy

Done in 6 children

  1. Data are given as absolute numbers or mean ± SD.