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Figure 5 | Orphanet Journal of Rare Diseases

Figure 5

From: A mutation in the c-Fos gene associated with congenital generalized lipodystrophy

Figure 5

Gene expression alterations due to diminished c-fos expression. A) Gene expression date were analyzed for statistically significant different gene expression (1.5-fold difference; p<0.05). Resulting transcript IDs were subjected to automated annotation for conserved AP-1 transcription factor binding sites. B) The pathways showing altered transcriptional regulation were deduced from differential gene expression identified. Colored genes (red and green) were identified differentially regulated by microarray analysis. Genes directly regulated by c-fos are indicated (blue line). Predicted transcription factors (white) involved in observed gene regulation were deduced using Ingenuity Pathway Analysis ((IPA System (http://www.ingenuity.com).

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