Kidney biopsy. A) PAS staining. Histology of the kidney with characteristic changes of advanced Fabry nephropathy. Please note glomerular segmental sclerosis (A), adhesion and Bowman capsule reduplication (B), tubular atrophy and tubular cell related fibrosis (thickened basement membranes) (C) and arteriolar hyalinosis (D). Original magnification 63×. Courtesy of Prof. Justus Müller, Department of Pathology, University Hospital of Würzburg, Würzburg, Germany. B) Sirius red staining of collagen fibers illustrates peri-glomerular fibrosis (E) and interstitial fibrosis (F). Original magnification × 20.