Skip to main content
Figure 5 | Orphanet Journal of Rare Diseases

Figure 5

From: Compounds that correct F508del-CFTR trafficking can also correct other protein trafficking diseases: an in vitro study using cell lines

Figure 5

F508del-CFTR correctors result in functional hERG G601S channels. Representative patch clamping traces are shown for vehicle-treated cells (A), astemizole treatment and washout (B), KM57 treatment and washout (C), KM60 treatment and washout (D), and glafenine treatment and washout (E). Quantitative analysis of the tail currents is shown in (F). Only KM57 treatment resulted in a significant increase in tail currents using one-way ANOVA and Bonferroni’s multiple comparison test (p =0.0131). Numbers below the treatments indicate n.

Back to article page

Orphanet Journal of Rare Diseases

ISSN: 1750-1172