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Figure 3 | Orphanet Journal of Rare Diseases

Figure 3

From: Compounds that correct F508del-CFTR trafficking can also correct other protein trafficking diseases: an in vitro study using cell lines

Figure 3

Ouabain treatment induces an intermediate hERG G601S glycosylation state. (A) Representative blot showing hERG G601S treated with increasing concentrations of ouabain in the absence (−) and presence of endoglycosidase enzymes Endo H (H), PNGase F (F), as indicated. Treatment with vehicle (DMSO) and astemizole are shown as negative and positive controls for correction. Core, intermediate, and complex-glycosylated hERG are marked by arrows. (B) Tubulin is shown as a loading control.

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Orphanet Journal of Rare Diseases

ISSN: 1750-1172