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Table 1 Biological features of patients

From: Partial lipodystrophy with severe insulin resistance and adult progeria Werner syndrome

  Patient 1 Patient 2 Normal values
Fasting glycemia (mmol/L) 5.1 4.9 4-5.6
Fasting insulinemia (pmol/L) 168 371 13-100
2 h post-OGTT glycemia (mmol/L) 6.5 12.2 4–7.4
2 h post-OGTT insulinemia (pmol/L) 29750 8884 90–520
HbA1c (%) 6.8 6.1 < 5.5
Total cholesterol (mmol/L) 4.8 5.8 4-5.5
LDL-cholesterol (mmol/L) 3.6 3.5 1.2-4.1
HDL-cholesterol (mmol/L) 0.75 0.98 1-2
Triglycerides (mmol/L) 2.4 2.8 0.55-1.6
Alanine transaminase (ALT) (IU/L) 47 75 10-40
Aspartate transaminase (AST) (IU/L) 24 34 10-32
Gamma-glutamyl transferase (GGT) (IU/L) 60 113 8-54
Leptin (μg/L) 33 8.6 2.4-25
Adiponectin (mg/L) 0.8 1.9 3.9-12.9
Sex-hormone binding globulin (nmol/L) 14 16.1 40-80
Insulin-like growth factor 1 (IGF-1) (μg/L) 166 313 175-375 at age 30-40
Thyroid stimulating hormone (TSH) (mU/L) 4.8 3.8 0.8-4.8
Free T4 (μg/L) 9.4 8.6 7.5-21.1
Follicle stimulating hormone (FSH) (IU/L) 7.5 6.4 2-13
Luteinizing hormone (LH) (IU/L) 3.2 4.6 1.5-11
Estradiol (pmol/L) 215 480 80-370
Total testosterone (nmol/L) 0.96 1.7 0.3-1.85
Androstenedione (nmol/L) 4.9 13.5 2-11.4
Dehydroepiandrosterone sulfate (mmol/L) 2.4 1.8 0.9-11.6
Prolactin (μg/L) 6.6 5.4 3-27
Anti-Müllerian hormone (pmol/L) <0.3 <0.3 3.6-62
Inhibin B (ng/L) < 10 < 10 60-125
  1. OGTT oral glucose tolerance test.
  2. Hormone measurements were performed in early follicular phase.
  3. Anti-Müllerian hormone and inhibin B levels were measured at age 33 for patient 1.