KL-6, a Human MUC1 Mucin, as a prognostic marker for diffuse alveolar hemorrhage syndrome

Table 2 Cox’s proportional analysis of the overall survival

Variable	Unfavorable/Favorable	β	HR (95%CI)	p-value^*
Univariate analysis
Age(yrs)	<70/ ≥70	0.34	1.40 (0.66-2.97)	0.38
Sex	female/ male	0.18	1.99 (0.56-2.58)	0.64
Smoking status	never/ smoker	0.43	1.54 (0.67-3.55)	0.31
Pulmonary involvement	bilateral/ unilateral	0.70	2.02 (0.68-6.02)	0.21
Baseline P/F ratio	<200/ ≥200	0.47	1.60 (0.74-3.45)	0.23
P/F ratio 48 hrs after admission	<200/ ≥200	0.95	2.58 (1.17-5.68)	0.018
PT-INR	≥2/ <2	0.10	1.11 (0.38-3.23)	0.85
APTT (sec)	≥30/ <30	0.28	1.33 (0.56-3.17)	0.52
Baseline KL-6 level (U/mL)	≥240/ <240	1.55	4.72 (1.63-13.7)	0.004
Maximum KL-6 level (U/mL)	≥700/ <700	1.49	4.43 (1.76-11.1)	0.002
Multivariate analysis *
Baseline KL-6 level (U/mL)	≥240/ <240	0.99	2.70 (0.75-9.67)	0.13
Maximum KL-6 level (U/mL)	≥700/ <700	1.37	3.95 (1.14-13.7)	0.031

HR, hazard ratio; CI, confidence interval; GGA, ground glass attenuation; P/F, PaO₂/F_IO₂.
PT-INR, prothrombin time-international normalized ratio.
APTT, activated partial thromboplastin time.
* Adjusted for age, sex, smoking status, extent of pulmonary involvement and P/F ratio 48 hrs after admission.

ISSN: 1750-1172