Table 1 Differences in clinical characteristics between survivors and non-survivors with DAH
From: KL-6, a Human MUC1 Mucin, as a prognostic marker for diffuse alveolar hemorrhage syndrome
Variables | Survivors, n(%) | Non-survivors, n(%) | p-value |
|---|---|---|---|
(n=13) | (n=28) | ||
Age ≥70(yrs) | 3 (23) | 16 (57) | 0.052* |
Male sex | 8 (62) | 17 (61) | >0.99* |
Never smoker | 7 (54) | 19 (70) | 0.48* |
Bilateral pulmonary involvement | 9 (69) | 24 (86) | 0.24* |
Consolidation on chest x-ray | 7 (54) | 15 (54) | >0.99* |
GGA on chest x-ray | 9 (69) | 22 (79) | 0.70* |
Use of mechanical ventilation | 10 (77) | 26 (93) | 0.30* |
Mode of mechanical ventilation | 0.28* | ||
SIMV | 5 (12) | 9 (22) | |
APRV | 3 (7) | 8 (20) | |
HFOV | 0 (0) | 6 (15) | |
CPAP/ PSV | 2 (5) | 1 (2) | |
O2 mask/ NIPPV | 3 (7) | 4 (10) | |
Preceding interstitial pneumonia | 0 (0) | 3 (11) | 0.54* |
Treatment | |||
Methylprednisolone pulse | 5 (38) | 21 (75) | 0.038* |
Immunosupressant | 2 (15) | 5 (18) | >0.99* |
Plasema exchange | 1 (8) | 4 (14) | >0.99* |
Baseline PaO2/FIO2 ratio | 207±80 | 185±70 | 0.47# |
P/F ratio 48 hrs after admission | 314±86 | 250±114 | 0.023# |
Laboratory markers at admission | |||
PT-INR | 1.2±0.3 | 1.8±1.4 | 0.043# |
APTT (sec) | 29.6±4.7 | 42.0±18.0 | 0.029# |
D-dimer | 17.4±29.0 | 18.8±20.5 | 0.46# |
Platelet (x103/mL) | 185±88 | 142±103 | 0.09# |
Hemoglobin (g/mL) | 10.1±2.3 | 9.3±2.3 | 0.26# |
LDH (IU/L) | 567±399 | 736±1045 | 0.88# |
Duration of ICU stay (days) | 15±15 | 28±20 | 0.005# |