Material | Analyte | 2006 | 2007 | 2008 | 2009 |
---|---|---|---|---|---|
(30 centres) | (32 centres) | (32 centres) | (33 centres) | ||
Urine | ALAa | 30 | 32 | 32 | 33 |
PBGa,b | 30 | 32 | 32 | 33 | |
Total porphyrinsa | 25 | 27 | 28 | 29 | |
Fractionation of porphyrinsa,c | 30 | 30 | 31 | 31 | |
Faeces | Total porphyrinsa | 22 | 21 | 23 | 26 |
Fractionation of porphyrins with separation of copro I/IIIa,b,c | 23 | 25 | 28 | 28 | |
Fractionation of porphyrins without separation of copro I/III | 9 | 5 | 5 | 5 | |
Plasma | Plasma fluorescence scanninga,b,c | 25 | 29 | 29 | 29 |
Total porphyrins | 11 | 13 | 15 | 16 | |
Fractionation of porphyrins | 16 | 9 | 11 | 11 | |
ALA | not asked | not asked | not asked | 3 | |
PBG | not asked | not asked | not asked | 3 | |
Whole blood | Erythrocyte total protoporphyrina,d | 23 | 27 | 28 | 30 |
Erythrocyte free and zinc-chelated protoporphyrin a,d | 20 | 24 | 23 | 26 | |
Porphobilinogen deaminase activity | 20 | 22 | 22 | 23 | |
Uroporphyrinogen decarboxylase activity | 12 | 9 | 7 | 10 | |
Other enzyme analysese | 12 | 12 | 8 | 10 | |
DNA analyses | Hydroxymethylbilane synthase gene | 19 | 16 | 18 | 17 |
Uroporphyrinogen III synthase gene | 8 | 3 | 1 | 9 | |
Uroporphyrinogen III decarboxylase gene | 13 | 10 | 10 | 12 | |
Coproporphyrinogen III oxidase gene | 11 | 13 | 13 | 12 | |
Protoporphyrinogen oxidase gene | 19 | 17 | 18 | 17 | |
Ferrochelatase gene | 16 | 13 | 14 | 15 | |
ALA synthase 1 gene | not asked | not asked | 0 | 1 | |
ALA synthase 2 gene | not asked | not asked | 4 | 7 |