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Figure 3 | Orphanet Journal of Rare Diseases

Figure 3

From: Clinical features and predictors for disease natural progression in adults with Pompe disease: a nationwide prospective observational study

Figure 3

Longitudinal changes in muscle strength. Rate of disease progression measured by manual muscle testing (MRC sumscore) (A) and hand-held dynamometry (HHD sumscore) (B) related to follow-up duration measured from time of inclusion in the study for 66 adults with Pompe disease. The figure shows the measured values and regression lines at group level for the following subgroups: 1) Patients with normal pulmonary function (FVC ≥80% predicted) and disease duration <15 years (circles, black line); 2) patients with normal pulmonary function (FVC ≥80% predicted) and disease duration ≥ 15 years (red squares, red line); 3) patients with abnormal pulmonary function (FVC <80% predicted) and disease duration <15 years (green triangles, green line); and 4) patients with abnormal pulmonary function (FVC <80% predicted) and disease duration ≥ 15 years (blue asterisks, blue line).

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