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Table 5 Associations of ART with risk of ARM according to plurality of birth

From: Assisted reproductive techniques and the risk of anorectal malformations: a German case-control study

Plurality of birth

ART

Population-based controls N (%)

All ARM cases

Prospectively collected ARM cases in 2009 to 2011

   

N (%)

OR (95% CI)

P value

N (%)

OR (95% CI)

P value

Singletons

No

9,664,317 (99%)

249 (94%)

1.0 (Reference)

-

116 (94%)

1.0 (Reference)

-

 

Yes

81,039 (1%)

16 (6%)

7.7 (4.6–12.7)

<0.0001

7 (6%)

7.2 (3.4–15.4)

<0.0001

Multiple births

No

275,687 (85%)

16 (53%)

1.0 (Reference)

-

5 (42%)

1.0 (Reference)

-

 

Yes

48,943 (15%)

14 (47%)

4.9 (2.4–10.1)

<0.0001

7 (58%)

7.9 (2.5–24.9)

<0.0001

  1. ART = assisted reproductive techniques, OR = odds ratio, CI = confidence interval.