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Table 2 Univariate analysis of selected characteristics for associations with the presence of internal neurofibromas in 357 children with neurofibromatosis-1

From: Clinical characteristics predicting internal neurofibromas in 357 children with neurofibromatosis-1: results from a cross-selectional study

 

Internal neurofibromas

Odds ratio (95% CI)†

P value‡

 

No

Yes

  
 

n = 322

n = 35

  

Male gender

148 (46)

16 (46)

1.01 (0.49-2.07)

0.977

Age (years)

7.35 ± 4.87

10.67 ± 4.81

1.14 a (1.07-1.23)

<10 -4

Familial cases

166 (51)

17 (49)

0.61 (0.29-1.27)

0.184

Subcutaneous neurofibromas (n = 305/35)

53 (17)

19 (54)

4.51 (2.13-9.55)

<10 -4

Cutaneous neurofibromas

139 (43)

14 (40)

0.78 (0.37-1.64)

0.512

Plexiform neurofibromas (n = 140/33)

60 (43)

19 (70)

3.60 (1.55-8.34)

0.003

Café-au-lait spots

319 (99)

35 (100)

0.81 (0.04 - ∞)

1.000

Freckles (n = 312/34)

194 (56)

13 (28)

1.09 (0.47-2.52)

0.840

Lisch nodules (n = 250/23)

151 (60)

9 (39)

0.35 (0.14–0.86)

0.05

Xanthogranulomas (n = 257/32)

10 (4)

4 (13)

6.60 (1.69-25.74)

0.007

Short stature (n = 293/32)

32 (11)

4 (13)

1.00 (0.32-3.13)

0.996

Macrocephaly (n = 302/34)

12 (35)

73 (24)

1.65 (0.76-3.54)

0.203

Nonunion

1 (3)

12 (4)

1.8 (0.3-10.2)

0.684

Dysplasia (=314/35)

27 (9)

4 (11)

1.06 (0.34-3.35)

0.914

Facial asymmetry (n = 261/24)

20 (8)

3 (12)

1.23 (0.45-6.93)

0.419

Hypertension (n = 298/31)

2 (1)

1 (3)

5.41 (0.40-73.93)

0.205

  1. Odds ratio with 95% confidence interval (95% CI) by logistic regression adjusted for age.
  2. aOR with 95% CI giving the risk increase for a 1-year increase in age.
  3. P value by logistic regression, Data are numbers (%) or means ± 1 standard deviation.