Table 1 General characteristics of the 357 children with neurofibromatosis-1 included in the study
Clinical characteristics (n = missing data) | n (%) |
|---|---|
Male gender | 192 (53.8) |
Age at the first visit in years, mean ± SD (range) | 7.7 ± 5.0 (0.01-16.9) |
Familial case | 183 (51.3) |
Internal neurofibromas | 35 (9.8) |
Subcutaneous neurofibromas (n = 17) | 72 (20.2) |
Cutaneous neurofibromas | 153 (42.9) |
Plexiform neurofibromas (n = 184) | 83 (23.3) |
Café-au-lait spots | 354 (99.2) |
Freckles (n = 11) | 219 (61.3) |
Lisch nodules (n = 84) | 160 (44.8) |
Xanthogranulomas (n = 68) | 14 (3.9) |
Short stature (n = 32) | 36 (10.1) |
Macrocephaly (n = 21) | 85 (23.8) |
Nonunion | 13 (3.6) |
Dysplasia (n = 8) | 31 (8.7) |
Facial asymmetry (n = 72) | 23 (6.4) |
Hypertension (n = 28) | 3 (0.8) |