Figure 7
From: Rescue of nonsense mutations by amlexanox in human cells
Comparison of the efficiency of amlexanox alone or in combination with PTC-readthrough molecules. 6CFSMEo- cells were incubated with 5 μM (A) or 25 μM (B) of amlexanox alone or with G418 (upper panel) or PTC124 (lower panel). At time (t) = 2 min cAMP-stimulating cocktail was added (arrow). The increase in iodide efflux is shown as mean ± SEM from at least four independent experiments. Ft represents the measure of the fluorescence at the reading time; F0 is an average fluorescence before addition of cAMP agonists.