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Table 5 Updated organ response criteria

From: AL Amyloidosis

Organ Response criteria
Heart Mean interventricular septal thickness decreased by 2 mm, 20% improvement in ejection fraction, improvement by 2 NYHA classes without an increase in diuretic use, and no increase in wall thickness and/or a reduction (≥ 30% and ≥ 300 ng/L) of NT-proBNP in patients in whom the eGFR is ≥ 45 mL/min/1.73 m2
Kidney 50% decrease (at least 0.5 g/day) of 24-hr urine protein (urine protein must be > 0.5 g/day pre-treatment) in the absence of a reduction in eGFR ≥ 25% or an increase in serum creatinine ≥ 0.5 mg/dL
Liver 50% decrease in abnormal alkaline phosphatase value
  Decrease in liver size radiographically at least 2 cm
  1. Abbrevations : NYHA : New York Heart Association; NT-pro BNP, N-terminal pro-brain natriuretic peptide; eGFR, estimated glomerular filtration rate; NB : widely available methods for defining peripheral and autonomic nervous system response were felt not to exist.
  2. From Gertz et al. ( 3,4) with permission.