From: AL Amyloidosis
Organ | Response criteria |
---|---|
Heart | Mean interventricular septal thickness decreased by 2 mm, 20% improvement in ejection fraction, improvement by 2 NYHA classes without an increase in diuretic use, and no increase in wall thickness and/or a reduction (≥ 30% and ≥ 300 ng/L) of NT-proBNP in patients in whom the eGFR is ≥ 45 mL/min/1.73 m2 |
Kidney | 50% decrease (at least 0.5 g/day) of 24-hr urine protein (urine protein must be > 0.5 g/day pre-treatment) in the absence of a reduction in eGFR ≥ 25% or an increase in serum creatinine ≥ 0.5 mg/dL |
Liver | 50% decrease in abnormal alkaline phosphatase value |
 | Decrease in liver size radiographically at least 2 cm |