From: AL Amyloidosis
Involved organ or tissue | Criteria |
---|---|
Kidney | 24-hr urine protein > = 0.5 g/day, predominantly albumin |
Heart | NT-proBNP > 332 ng/l (in the absence of renal failure or atrial fibrillation) or mean wall thickness in diastole by echography > 12 mm, no other cardiac cause |
Liver | Total liver span > 15 cm in the absence of heart failure, or alkaline phosphatase > 1.5 times institutional upper limit of normal |
Nerve | Peripheral: Symmetric lower extremity sensorimotor peripheral neuropathy |
 | Autonomic: gastric-emptying disorder, pseudo-obstruction,voiding dysfunction not related to direct organ infiltration. |
Gastro-intestinal tract | Direct biopsy verification with symptoms |
Lung | Direct biopsy verification with symptoms |
 | Interstitial radiographic pattern |
Soft tissues | Tongue enlargement, arthropathy, claudication (presumed vascular amyloid), skin lesions, myopathy (by biopsy or pseudohypertrophy), lymph node (may be localized), carpal tunnel syndrome |