MRS investigations. Brain MRS obtained from the patient at baseline (4a, d) and at the end of the therapeutic trial (4b,e). In addition, an average spectrum from 3 comparison subjects is shown (4c, f). Note the absence of Gln (glutamine) at baseline (4a, d) and the increase of Glu + Gln (glutamate and glutamine) at the end of the trial (4b,e). Figures4a-c show the spectra acquired with the standard PRESS sequence, and figures4d-f show the MEGA-PRESS data.