Novel genetic linkage of rat Sp6 mutation to Amelogenesis imperfecta

Table 3 Abnormalities in AMI rats and Sp6 -deficient mice

Organ	Category	AMI rats this study, [42, 58]	*Sp6*-deficient mice [50, 51, 57]
Teeth	Number	Normal	Excess (hyperdontia)
	Enamel	Thin, calcified	Absence or thin
	Ameloblasts
	- Nuclear	Polarized	Not well-polarized
	-Tome’s process	No	Atypical
	-Morphological differentiation	Early regression	Defect
Hair		Normal	Short, alopecia, no fur
Whisker	Pups (at birth)	Curly	Rare, short, curly, alopecia
	Adult	Feeble	Delayed appearance
Digits		Normal	Syndactyly, oligodactyly

ISSN: 1750-1172