A long diagnostic delay in patients with Hereditary Haemorrhagic Telangiectasia: a questionnaire-based retrospective study

Table 4 Diagnosis Time Lag (DTL) in the 233 patients, according to Sex, Education Level, Affected Gene, and Index/Non-Index status

DIAGNOSIS TIME LAG (DTL)
				Univariate and Multivariate Analysis
				(a)	(b)	(c)
SEX
	Total	Males	Females
DTL, Mean ± SD (years) [Range]	25.7 ± 17.4	26.4 ± 19.2	25.1 ± 15.6	p = ns	p = ns	p = ns
DTL, Mean ± SD (years) [Range]	[0;73]	[0;73]	[0;62]	p = ns	p = ns	p = ns
EDUCATION LEVEL
	Low	Interm	High
DTL, Mean ± SD (years) [Range]	36.4 ± 18.0	24.5 ± 17.2	21.4 ± 15.2	P < 0.0001	P < 0.05	P < 0.01
DTL, Mean ± SD (years) [Range]	[0;73]	[0;65]	[0;64]	P < 0.0001	P < 0.05	P < 0.01
AFFECTED GENE
	HHT1	HHT2	HHT?
DTL, Mean ± SD (years) [Range]	27.7 ± 16.6	23.4 ± 17.3	33.1 ± 19.6	p = ns	P < 0.01	p = ns
DTL, Mean ± SD (years) [Range]	[0;68]	[0;73]	[2;61]	p = ns	P < 0.01	p = ns
INDEX/NON-INDEX STATUS	Index	Non-Index
DTL, Mean ± SD (years) [Range]	29.1 ± 18.0	22.6 ± 16.7		P < 0.01	p = ns	P < 0.05
DTL, Mean ± SD (years) [Range]	[0;73]	[0;68]

Univariate and multivariate analysis were performed as described in Methods section. (a) Univariate analysis, (b) Multivariate analysis before removal of age, (c) Multivariate analysis after removal of age.

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