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Table 2 First manifestation of HHT disease in the 233 patients, according to Sex, Education Level, Affected Gene, and Index/Non-Index status

From: A long diagnostic delay in patients with Hereditary Haemorrhagic Telangiectasia: a questionnaire-based retrospective study

ONSET OF HHT
SEX     
  Total Males Females  
Onset Age, Mean ± SD (years) 14.1 ± 11.2 14.6 ± 12.6 13.6 ± 9.7 p = ns
[Range] [3;60] [3;60] [3;50]
EDUCATION LEVEL     
  Low Interm High  
Onset Age, Mean ± SD (years) 17.2 ± 13.4 12.2 ± 9.8 13.8 ± 10.7 p = 0.115
[Range] [3;51] [3;60] [3;58]
AFFECTED GENE     
  HHT1 HHT2 HHT?  
Onset Age, Mean ± SD (years) 9.9 ± 8.6 16.6 ± 12.0 17.4 ± 14.4 P < 0.0001
[Range] [3;47] [3;58] [4;60]
INDEX/NON-INDEX STATUS     
  Index Non-Index   
Onset Age, Mean ± SD (years) 16.2 ± 13 12.1 ± 9.1   P < 0.02
[Range] [3;60] [3;49]   
CLINICAL ONSET Nr (%)   
Epistaxis alone 202 (86.7%)   
Epistaxis and Mucocut. Tel. 15 (6.4%)   
Epistaxis and GI bleeding 2 (0.9%)   
Epist., Mucocut. Tel, and GI bleeding 1 (0.5%)   
Mucocut Tel. (bleeding + non-bleeding) 6 (2.6%)   
GI bleeding 2 (0.9%)   
PAVM-related Accidents 2 (0.9%)   
CAVM-related Accidents 1 (0.5%)   
Asymptomatic (only Genetic testing) 2 (0.9%)