Skip to main content

Table 2 Number of breaks per cell in cultured lymphocytes from FA patients

From: Improvement of genetic stability in lymphocytes from Fanconi anemia patients through the combined effect of α-lipoic acid and N-acetylcysteine

Mean number of breaks per cell

Patients

Control group (n)

α-LA 20 μM (n)

% reduction

NAC 500 μM (n)

% reduction

α-LA 20 μM +

NAC 500 μM (n)

% reduction

FA1

0.26 (100)

0.09 (100)

65.38

_

_

_

_

FA2

0.27 (100)

0.14 (100)

48.15

_

_

_

_

FA3

0.28 (100)

0.15 (100)

46.43

_

_

_

_

FA4

0.62 (91)

0.29 (92)

53.23

_

_

_

_

FA5

1.50 (100)

0.94 (100)

37.33

_

_

_

_

FA6

0.75 (100)

0.50 (76)

33.33

_

_

_

_

FA7

1.50 (50)

1.50 (50)

0.00

_

_

_

_

FA8

0.19 (100)

0.16 (50)

15.79

0.16 (50)

15.79

0.16 (50)

15.79

FA9

0.26 (50)

0.12 (50)

53.85

0.06 (50)

76.92

0.04 (50)

84.62

FA10

0.30 (50)

0.14 (50)

53.33

0.08 (50)

73.33

0.04 (50)

86.67

FA11

0.22 (50)

0.18 (50)

18.18

0.10 (50)

54.55

0.06 (50)

72.73

FA12

0.24 (50)

0.08 (50)

66.67

0.18 (50)

25.00

0.06 (50)

75.00

FA13

0.30 (50)

0.44 (50)

0.00

0.26 (50)

13.33

0.20 (50)

33.33

FA14

0.31 (100)

_

_

0.24 (50)

22.58

0.20 (50)

35.48

Mean ± SD

0.500 ± 0.452

0.364 ± 0.417

 

0.154 ± 0.078

 

0.109 ± 0.075

 
  1. In control group no antioxidant treatment was done. The effect of the antioxidants was calculated by the percentage of reduction of the number of breaks per cell in the α-LA, NAC and α-LA plus NAC treatments relatively to control group. ― Unavailable data. Abbreviations are explained in Table 1. Paired t-test: Control group vs α-LA 20 μM P < 0.01; Control group vs NAC 500 μM P < 0.01; Control group vs α-LA 20 μM + NAC 500 μM P < 0.01; α-LA 20 μM vs α-LA 20 μM + NAC 500 μM P < 0.05; NAC 500 μM vs α-LA 20 μM + NAC 500 μM P < 0.01.