Orphanet Journal of Rare Diseases

Table 1 Number of DEB-induced breaks per cell in cultured lymphocytes from healthy donors

From: Improvement of genetic stability in lymphocytes from Fanconi anemia patients through the combined effect of α-lipoic acid and N-acetylcysteine

Number of breaks per cell
Healthy donors	Control group (n)	α-LA 20 μM (n)	% reduction	Healthy donors	Control group (n)	NAC 500 μM (n)	% reduction
HD1	0,09 (100)	0,09 (100)	0,00	HD14	0,20 (41)	0,14 (50)	30,00
HD2	0,09 (100)	0,06 (100)	33,33	HD15	0,14 (50)	0,12 (50)	14,29
HD3	0,07 (100)	0,07 (100)	0,00	HD16	0,12 (50)	0,04 (50)	66,67
HD4	0,08 (100)	0,03 (100)	62,50	HD17	0,10 (50)	0,12 (50)	0,00
HD5	0,04 (100)	0,01 (100)	75,00	HD18	0,12 (50)	0,08 (50)	33,33
HD6	0,44 (100)	0,12 (100)	72,73	HD19	0,22 (50)	0,16 (50)	27,27
HD7	0,12 (100)	0,11 (100)	8,33	HD20	0,32 (50)	0,14 (50)	56,25
HD8	0,08 (100)	0,09 (100)	0,00	HD21	0,14 (50)	0,10 (50)	28,57
HD9	0,09 (100)	0,10 (100)	0,00	HD22	1,14 (50)	1,00 (50)	12,28
HD10	0,10 (100)	0,11 (100)	0,00	HD23	0,18 (51)	0,12 (50)	33,33
HD11	0,18 (50)	0,08 (100)	55,56	HD24	0,13 (100)	0,20 (50)	0,00
HD12	0,19 (53)	0,22 (100)	0,00	_	_	_	_
HD13	0,15 (100)	0,06 (100)	60,00	_	_	_	_
Mean ± SD	0.132 ± 0.102	0.088 ± 0.051		Mean ± SD	0.255 ± 0.300	0.202 ± 0.268

In control group no antioxidant treatment was done. The effect of the antioxidants was calculated by the percentage of reduction of the number of breaks per cell in α-LA and NAC treatments relatively to control group. ― Unavailable data; α-LA indicates α-lipoic acid; NAC indicates N-acetylcysteine; n indicates the number of cells analyzed. Paired t-test: Control group vs NAC 500 μM P < 0.05.

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ISSN: 1750-1172

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