Table 1 Past, present and future of hemophilia treatment
From: Past, present and future of hemophilia: a narrative review
Year | Main events |
|---|---|
1970s: a golden era | |
1970s | Lyophilized factors, home treatment, pioneer prophylaxis programs, comprehensive treatment centers |
1977 | Desmopressin |
1980s: many shadows, a few lights | |
1982 | Factor IX gene cloned, AIDS |
1983 | Early virucidal methods (dry-heating) |
1984 | Factor VIII gene cloned, HIV isolated |
1985 | Anti-HIV testing |
1987 | Safe virus-inactivated plasma factors |
1989 | Recombinant FVIII |
1990s: a new golden era | |
1994 | Immune tolerance |
1996 | HAART for HIV |
1996 | Recombinant FVIIa |
1997 | Recombinant FIX |
2000s: current hemophilia therapy | |
2000-2006 | First gene therapy trials |
2002 | HCV eradication by IFN-RBV |
The next 10 years | |
2011-2021 | More factor concentrate available worldwide Longer-acting recombinant coagulation factors Fusion coagulation factors Cure of hemophilia: gene transfer |