From: Capturing phenotypic heterogeneity in MPS I: results of an international consensus procedure
'results, 1st written round' Considered to be of major importance by the majority and redundant by none of the experts | 'results, 2nd written round' Resulting from statistical comparisons of the median expert scores | 'results, consensus meeting' Final consensus list | |
---|---|---|---|
Cognitive decline | x | ||
Age at onset of symptoms | x | x | x |
Developmental delay | x | x | x |
Hydrocephalus | x | ||
Kyphosis | x | x | x |
Obstructive sleep apnea syndrome | x | E | |
Joint stiffness/arthropathy/contractures | x | x | |
Large head/frontal bossing | x | x | |
Early diagnosis | x | ||
Dysostosis multiplex | x | E | |
Coarse facial features | x | ||
Cardiomyopathy | x | ||
Growth retardation | E |