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Table 2 Copy number variation data in controls and LFS/LFL patients classified according to TP53 mutation type

From: Number of rare germline CNVs and TP53 mutation types

  Controls p.R337H carriers DBD mutation carriers
Number of individuals 100 12 9
Number of CNVs 702 92 66
Common 679 89 56
Rare 23 3 10
Average number of all CNVs per diploid genome 7.0±3.1 7.7±2.2 7.3±2.5
Average number of rare CNVs per diploid genome 0.2±0.4 0.2±0.6 1.1±1.3 a
Proportion of rare/common CNVs 0.034 0.034 b 0.179 c
  1. a. difference between controls and DBD mutation carriers (p=0.0026**).
  2. b. difference between p.R337H and DBD mutation carriers (p=0.0156*).
  3. c. difference between controls and DBD mutation carriers (p=0.0002***).