ID | Classification | Gender | TP53 mutation | Effect | p53 protein domain function | Tumor type (age) |
---|---|---|---|---|---|---|
Y1T0 | Chompret | F | R213Q CGA>CAA | Missense | DNA binding | Hydathiform mole (23), Ampulla of Vater (41) |
Y33T0 | LFL Birch | F | V173M GTG>ATG | Missense | DNA binding | Soft tissue sarcoma (23), Breast (43) |
Y53T0 | Eeles1 | F | G245S GGC>AGC | Missense | DNA binding | Bilateral breast (36), Gall bladder (?) |
Y57T0 | Eeles1 | F | G244D GGC>GAC | Missense | DNA binding | Breast (40), Colorectal (?) |
Y65T0 | Chompret | F | V197M GTG >ATG | Missense | DNA binding | Colorectal (45), Lung (51), Soft tissue sarcoma (51) |
Y79T0 | Chompret | F | T125T ACG>ACA | Splice | DNA binding | Adrenal carcinoma (1) |
Y87T0 | LFL/Chompret | M | S241Y TCC>TAC | Missense | DNA binding | Rhabdomyosarcoma (2), Choroid plexus tumor (7), Liposarcoma (10) |
Y97T1 | LFS | F | IVS8+1G>A | Splice | DNA binding | Breast (27) |
Y103T2 | LFL/Chompret | F | H214Q | Missense | DNA binding | Breast (62) |
Y12T1 | LFS | F | R337H CGC>CAC | Missense | Tetramerisation | Soft tissue sarcoma (58), Breast (59), Thyroid (61), Soft tissue sarcoma (62) |
Y15T0 | Chompret | F | R337H CGC>CAC | Missense | Tetramerisation | Adrenal carcinoma (6), Kidney (7) |
Y27T0 | LFL Birch | F | R337H CGC>CAC | Missense | Tetramerisation | Breast (36) |
Y49T1 | Eeles 1 | M | R337H CGC>CAC | Missense | Tetramerisation | Kidney (64) |
Y99T0 | Chompret | F | R337H CGC>CAC | Missense | Tetramerisation | Breast (32) |
Y100T0 | LFS | F | R337H CGC>CAC | Missense | Tetramerisation | Breast (46) |
Y106T0 | Chompret | F | R337H CGC>CAC | Missense | Tetramerisation | Breast (43) |
Y107T0 | LFS | M | R337H CGC>CAC | Missense | Tetramerisation | Adrenal carcinoma (2) |
Y127T0 | Chompret | M | R337H CGC>CAC | Missense | Tetramerisation | Adrenal carcinoma (3) |
Y131T0 | LFS | F | R337H CGC>CAC | Missense | Tetramerisation | Leg synovial sarcoma (32) |
Y144T0 | Chompret | F | R337H CGC>CAC | Missense | Tetramerisation | Breast (29) |
Y154T0 | Chompret | F | R337H CGC>CAC | Missense | Tetramerisation | Breast (48) |