From: Population pharmacokinetics and pharmacodynamics of cysteamine in nephropathic cystinosis patients
Residual cysteamine concentration (μmoL/L) median (sd) | ||||
---|---|---|---|---|
WT | Current Recommendations | Study recommendations | ||
Patients with cystine > 2 | Patients with cystine < 2 | pvalue | ||
10-17 kg | 1.7 (2.8) | 4.8 (5.7) | < 10 -4 | 4.3 (7.0) |
17-25 kg | 2.1 (4.0) | 6.1 (7.3) | < 10 -4 | 5.4 (9.2) |
25-40 kg | 2.6 (3.9) | 6.4 (7.6) | < 10 -4 | 6.5 (9.4) |
40-70 kg | 3.3 (4.5) | 7 (7.9) | < 10 -4 | 7.9 (10.6) |