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Table 3 Residual cysteamine (6-hour post-dose) concentrations (μmoL/L) obtained with current recommendations and this study recommendations according to bodyweight groups.

From: Population pharmacokinetics and pharmacodynamics of cysteamine in nephropathic cystinosis patients

 

Residual cysteamine concentration (μmoL/L) median (sd)

WT

Current Recommendations

Study recommendations

 

Patients with cystine > 2

Patients with cystine < 2

pvalue

 

10-17 kg

1.7 (2.8)

4.8 (5.7)

< 10 -4

4.3 (7.0)

17-25 kg

2.1 (4.0)

6.1 (7.3)

< 10 -4

5.4 (9.2)

25-40 kg

2.6 (3.9)

6.4 (7.6)

< 10 -4

6.5 (9.4)

40-70 kg

3.3 (4.5)

7 (7.9)

< 10 -4

7.9 (10.6)