Biomarker analysis of Morquio syndrome: identification of disease state and drug responsive markers

Table 5 Analytes significantly correlated with uKS levels in MPS IVA subjects

Analyte	p-value
Significantly higher with high uKS (> 24.6 g/mg creatinine) versus lower levels
Alpha-2 macroglobulin†	0.029
Growth hormone†	0.003
ICAM-1 (intracellular adhesion molecule-1)†	0.007
MIP-1 alpha (macrophage inflammatory protein-1 alpha)‡	0.022
MMP-2 (matrix metalloproteinase-2)‡	0.024
SHBG (sex hormone-binding globulin)	0.029
TNF-alpha (tumor necrosis factor alpha)†	0.005
Thyroxine binding globulin	0.000
VCAM-1 (vascular cell adhesion molecule-1)†	0.003
Significantly higher with low uKS (< 24.6 μg/mg creatinine) versus higher levels
Brain-derived neurotrophic factor	0.045
IgA (immunoglobulin A)†	0.008
IgM (immunoglobulin M)†	0.005
Insulin§	0.011
Leptin‡	0.010
Lipoprotein (a)‡	0.032
Serum amyloid P‡	0.005

† These analytes were also significantly different between the high and low age groups.
‡ These analytes were also significantly different between MPS IVA patients and unaffected controls.
§ This analyte was also significantly different between the high and low 6MWT groups.

ISSN: 1750-1172