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Table 3 Analytes significantly correlated with age in MPS IVA subjects

From: Biomarker analysis of Morquio syndrome: identification of disease state and drug responsive markers

Analyte

p-value

Significantly higher in older patients (> 9.5 years) versus younger patients

IGF-1 (insulin-like growth factor-1)

0.010

IgA (immunoglobulin A)*

0.002

IgM (immunoglobulin M)*

0.004

Significantly higher in younger patients (< 9.5 years) versus older patients

Calcitonin

0.015

G-CSF (granulocyte colony-stimulating factor)

0.044

Growth hormone*

0.003

ICAM-1 (intracellular adhesion molecule-1)*

0.000

MMP-2 (matrix metalloproteinase-2)*‡

0.019

TNF-alpha (tumor necrosis factor alpha)*

0.000

TSH (thyroid stimulating hormone)

0.023

VCAM-1 (vascular cell adhesion molecule-1)*

0.009

  1. * These analytes were also significantly different between high and low uKS groups (see Table 5).
  2. ‡This analyte was also significantly different between MPS IVA patients and unaffected controls (see Table 2).