Table 1 Patient demographic and clinical characteristics
Patient | Sex | Age at diagnosis of LCH (years) | Age at diagnosis of CNS involvement (years) | Localisation of CNS mass lesion | Other sites of LCH involvement | Symptoms |
|---|---|---|---|---|---|---|
1 | F | 10 | 12 | hp | Bone, skin | Diabetes insipidus |
2 | F | 50 | 53 | p (brainstem) | mastoid | Cerebellar ataxia |
3 | F | 26 | 28 | hp | None | Cognitive impairment, bulimia, diabetes insipidus |
4 | M | 9 | 9 | hp | None | Diabetes insipidus |
5 | M | 21 | 34 | p (multifocal: frontal and brainstem) | Bone, lung | Cerebellar ataxia, cranial nerve palsies, hemiparesis, diabetes insipidus |
6 | F | 2 | 3 | hp | Skin | Diabetes insipidus |
7 | M | 41 | 44 | hp | Lung | Cognitive impairment, diabetes insipidus |
8 | F | 3 | 3 | hp | Skin, bone, thyroid | Diabetes insipidus |
9 | F | 7 | 7 | hp | Skin, lung | Diabetes insipidus |
10 | F | 1 | 10 | hp | Skin, bone, | Visual field defect |
11 | F | 4 | 4 | hp and m | Bone | Diabetes insipidus |
12 | M | 26 | 30 | hp and p (brainstem) | Skin, lung, parotid, liver | Hemiparesis, headaches |
13 | M | 35 | 35 | hp | Bone | Diabetes insipidus |
14 | F | 15 | 16 | hp | None | Headaches |
15 | F | 2 | 12 | p (multifocal: temporal, frontal, parietal lobes) | Bone, skin | Diabetes insipidus |
16 | M | 28 | 28 | hp | Bone | Cognitive impairment, diabetes insipidus |
17 | F | 15 | 15 | hp | None | Visual field defect, diabetes insipidus |
18 | M | 1 | 5, 5 | hp | Bone, skin | Diabetes insipidus |
19 | F | 12 | 12, 1 | hp | None | Diabetes insipidus |
20 | M | 11 | 11 | p (cerebellum) | None | Cerebellar ataxia |