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Table 2 Immunohistochemistry findings in small cell carcinoma of the urinary bladder.

From: A rare bladder cancer - small cell carcinoma: review and update

Antibody

No of studies

% of positives staining (mean)

Neuroendocrine markers

NSE[2, 9, 11, 23]

4

25-100% (88.5%)

Synaptophysin[2, 11, 9]

3

66.6-76% (72.4%)

Serotonin[23]

1

78%

Chromogranin[2, 9, 11, 17]

4

22-89% (50%)

Epithelial markers

Cytokeratin[2, 23]

2

70-77% (75%)

EMA[2]

1

77.7%

CK7[24]

1

59%

CAM 5.2[2, 11, 9]

3

47-66.6% (41%)

Other markers

S-100 protein[23]

1

40%

TTF1[24, 25]

2

39-50% (40%)

EGFR[9, 26]

2

27-36% (28.6%)

C-KIT[9, 27]

2

22-27% (27%)

CD44v6[11]

1

7%

PDGFR[28]

1 case report

+

  1. Abbreviations. NSE = neuron specific enolase; EMA = epithelial membrane antigen; CK7 = cytokeratine 7; EGFR = epidermal growth factor receptor; PDGFR = platelet derived growth factor