Figure 1

Pathology of small cell carcinoma of the bladder [31, 43]. A. Hematoxylin and eosin (H and E) staining of the biopsy specimen, low-power view: Urothelial mucosa unfiltered by poorly differentiated carcinomatous proliferation comprised sheets of monomorphic cells. B. Hematoxylin and eosin (H and E) staining of the biopsy specimen, high-power view (×20): Proliferation comprised small cells with hyperchromatic nuclei infiltrating the muscle. C. Hematoxylin and eosin (H and E) staining: High-power view (×40) of a transurethral resection of small cell carcinoma, showing typical scant cytoplasm, increased mitotic index, spindling, and prominent nuclear moulding. D. Immunostaining: NSE-antibody-positive bladder tumor cells