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Table 1 The XP genes

From: Xeroderma pigmentosum

Gene No of exons Chromosomal locationa Protein size (aa) Protein function Defective pathway
XPA 6 9q22.33 273 Damage verification NER
XPB/ERCC3 15 2q14.3 782 Helicase NER
XPC 16 3p25.1 940 Damage recognition NER (GGR)
XPD/ERCC2 23 19q13.32 760 Helicase NER
XPE/DDB2 10 11p11.2 427 Damage recognition NER (GGR)
XPF/ERCC4 11 16p13.12 916 Nuclease NER
XPG/ERCC5 15 13q33.1 1186 Nuclease NER
XPV/POLH 11 6p21.1 713 Polymerase TLS
  1. Abbreviations. NER: Nucleotide excision repair; GGR: global genome repair sub-pathway; TLS: translesion synthesis.
  2. a From [23].