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Figure 3 | Orphanet Journal of Rare Diseases

Figure 3

From: Consequences of a global enzyme shortage of agalsidase beta in adult Dutch Fabry patients

Figure 3

Individual plasma lysoGb3 levels before and after approximately 1 year of shortage for 3a. males and 3b. females. In males a significant increase of lysoGb3 is seen after 1 year of shortage. 3c. Males with (AB+, solid line) and without antibodies (AB-, dashed line) do not show a significant difference in lysoGb3 increase. 3d. Percentage increase of lysoGb3 after 1 year of shortage in the continued agalsidase group vs. later switch group (males only). The continued agalsidase group was dose reduced from 0.5 mg to 0.25 mg/kg/eow. The later switch group was first dose reduced to 0.5 mg/kg/eow agalsidase beta and subsequently switched tot agalsidase alpha 0.2 mg/kg/eow. In the continued agalsidase beta group median lysoGb3 value at start of shortage (= 100%) was 31.5 nM and 16.4 nM in the switch group. Abbreviations: Fz: continued agalsidase beta group (blue line), switch: later switch group (red line).

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