Figure 2

Neuroimaging. ChAc. Coronal FLAIR- (A) and axial T1-weighted (B) images demonstrate moderate atrophy of the caudate nucleus. MLS. Axial T2-weighted images demonstrate moderate atrophy of caudate nucleus and putamen (C) but no relevant cortical atrophy (D). HDL2. Axial FLAIR- (E) and coronal T1-weighted images (F) demonstrate atrophy of the caudate nucleus and the fronto-temporal cortex. In addition, FLAIR images show periventricular white matter hyperintensities (courtesy of Nora Chan, MD, UCLA, Los Angeles, USA). PKAN. T2-weighted fast spin echo (G) and T1-weighted (H) brain MRI scans from a child with PKAN demonstrating the "eye of the tiger" sign (courtesy of Susan J. Hayflick, MD, Oregon Health and Science University, Portland, Oregon, USA)