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Figure 3 | Orphanet Journal of Rare Diseases

Figure 3

From: Therapy of Fabry disease with pharmacological chaperones: from in silico predictions to in vitro tests

Figure 3

The active site of human lysosomal alpha-galactosidase. The active site of alpha-galactosidase is sketched as a wireframe coloured by atom type showing the side chains of residues which directly bind 1-deoxy-galactonojirimycin (D92, D93, D170, D231,E203, K168, R227), the side chains of C142, A230,S297 and the backbone of the peptide, ranging from 229 to 232, in poly-proline II helix conformation. Arrows run alongside carbonyl bonds. 1-deoxy-galactonojirimycin is coloured in green.

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Orphanet Journal of Rare Diseases

ISSN: 1750-1172