Figure 8

The various subgroups of hemolytic uremic syndrome and thrombotic thrombocytopenic purpura according to age at onset. Pink arrows and boxes: complement-HUS; green arrows and boxes: TTP; upper line: immune HUS and TTP; lower line: hereditary HUS and TTP. The figure also shows the 2 main infection-induced HUS (blue arrows and boxes) and the various causes of secondary atypical HUS (violet boxes), according to age. HUS: hemolytic uremic syndrome; TTP: thrombotic thrombocytopenic purpura; HIV: human immunodeficiency virus; STEC: Shiga-toxin producing Escherichia coli; ADAMTS 13, A Desintegrin And Metalloproteinase with a ThromboSpondin type 1 motif, member 13.