Skip to main content


Springer Nature is making SARS-CoV-2 and COVID-19 research free. View research | View latest news | Sign up for updates

Figure 1 | Orphanet Journal of Rare Diseases

Figure 1

From: Atypical hemolytic uremic syndrome

Figure 1

The 3 pathways of complement activation. Classical, lectin and alternative pathways converge at the point of C3 activation. The lytic pathway then leads to the assembly of the membrane attack complex which destroys infectious agents. Regulators of the alternative pathway CFH, CFI and MCP cooperate to inactivate endothelial cell surface-bound C3b, thus protecting endothelial cells from complement attack. CFH: factor H; CFI: factor I; CFB: factor B; CFD: factor D; MCP: membrane cofactor protein.

Back to article page