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Table 4 Association between subcutaneous neurofibromas (SC-NFs) and several types of internal neurofibromas and peripheral neurofibromas

From: At-Risk Phenotype of Neurofibromatose-1 Patients: A Multicentre Case-Control Study

 

No SC-NFs (n = 102) Controls

2-9 SC-NFs (n = 85) OR** (95%CI)

≥10 SC-NFs (n = 21) OR** (95%CI)

Paraspinal neurofibromas

1

2.7 (1.4 - 5.3)

82 (10.4 - 647.9)

Distribution

   

None

-

1

1

Focal

1

2.4 (1.2 - 5.0)

10.3 (0.9 - 120.0)

Diffuse

1

5.4 (1.4 - 20.4)

492.0 (48.4 - 5006.2)

Location

   

None

-

1

1

Intradural

1

3.7 (0.9 - 15.0)

1270.0 (25.6 - 2849.8)

Extradural

1

2.4 (1.2 - 4.8)

45.0 (5.4 - 374.2)

Size

   

None

-

1

1

< 3 cm

1

2.3 (1.1 - 4.9)

58.6 (6.9 - 494.0)

≥3 cm

1

3.8 (1.4 - 10.4)

136.7 (14.9 - 1253.9)

Sciatic neurofibromas

1

4.3 (2.1 - 9.0)

29.1 (8.5 - 100.0)

Distribution

   

None

-

1

1

Focal

1

2.9 (1.2 - 7.0)

-

Diffuse

1

5.7 (1.5 - 21.7)

266.8 (41.6 - 1712.7)

Size

   

None

-

1

1

< 3 cm

1

4.2 (1.8 - 9.8)

27.2 (7.2 - 103.2)

≥3 cm

1

4.7 (1.4 - 15.5)

33.4 (6.6 - 167.6)

Neuropathies with SCV***

1

4.4 (0.9 - 22)

29.9 (5.5 - 162.3)

  1. *Reference category
  2. **Odds ratio with 95% confidence interval (95%CI) by multinomial logistic regression adjusted for matching variables (age, sex, hospital), using the control group of patients with neurofibromatosis type 1 and no SC-NFs (n = 102) as the reference category.
  3. *** Slowed conduction velocities