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Table 4 Association between subcutaneous neurofibromas (SC-NFs) and several types of internal neurofibromas and peripheral neurofibromas

From: At-Risk Phenotype of Neurofibromatose-1 Patients: A Multicentre Case-Control Study

  No SC-NFs (n = 102) Controls 2-9 SC-NFs (n = 85) OR** (95%CI) ≥10 SC-NFs (n = 21) OR** (95%CI)
Paraspinal neurofibromas 1 2.7 (1.4 - 5.3) 82 (10.4 - 647.9)
Distribution    
None - 1 1
Focal 1 2.4 (1.2 - 5.0) 10.3 (0.9 - 120.0)
Diffuse 1 5.4 (1.4 - 20.4) 492.0 (48.4 - 5006.2)
Location    
None - 1 1
Intradural 1 3.7 (0.9 - 15.0) 1270.0 (25.6 - 2849.8)
Extradural 1 2.4 (1.2 - 4.8) 45.0 (5.4 - 374.2)
Size    
None - 1 1
< 3 cm 1 2.3 (1.1 - 4.9) 58.6 (6.9 - 494.0)
≥3 cm 1 3.8 (1.4 - 10.4) 136.7 (14.9 - 1253.9)
Sciatic neurofibromas 1 4.3 (2.1 - 9.0) 29.1 (8.5 - 100.0)
Distribution    
None - 1 1
Focal 1 2.9 (1.2 - 7.0) -
Diffuse 1 5.7 (1.5 - 21.7) 266.8 (41.6 - 1712.7)
Size    
None - 1 1
< 3 cm 1 4.2 (1.8 - 9.8) 27.2 (7.2 - 103.2)
≥3 cm 1 4.7 (1.4 - 15.5) 33.4 (6.6 - 167.6)
Neuropathies with SCV*** 1 4.4 (0.9 - 22) 29.9 (5.5 - 162.3)
  1. *Reference category
  2. **Odds ratio with 95% confidence interval (95%CI) by multinomial logistic regression adjusted for matching variables (age, sex, hospital), using the control group of patients with neurofibromatosis type 1 and no SC-NFs (n = 102) as the reference category.
  3. *** Slowed conduction velocities