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Figure 4 | Orphanet Journal of Rare Diseases

Figure 4

From: Sensory and motor neuronopathy in a patient with the A382P TDP-43 mutation

Figure 4

Sequence traces and across-species conservation. (A) Sequence trace for the p.A382P variant; the patient is shown below the wild type sequence. The red square marks the substituted nucleotide and the substituted amino acid is in red. (B) Conservation across nine species of amino acids 377 to 405 of TDP-43 is shown using the Clustal W method. Amino acid 382 is boxed in red and the proline present in the mouse and rat is underlined in red.

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