Population pharmacokinetics and pharmacodynamics of hydroxyurea in sickle cell anemia patients, a basis for optimizing the dosing regimen

Table 5 Parameter estimates of the population MCV model

Parameters	Typical values (95% CI)	SD of IIV (95% CI)	Interindividual CV
K_in (%/day)	3.71 (3.13 - 4.30)	0.191 (0.083 - 0.401)	19%
K_out (day^-1)	0.042 (0.035 - 0.048)	0.186 (0.044 - 0.415)	19%
β (L. mg^-1)^1/γ	0.099 (0.064 - 0.135)	0.457 (0.336 - 0.599)	48%
γ (unitless)	0.19 (0.02 - 0.46)
θ_ΔHbF%(day^-1)	1.22 (-0.07 - 2.21)
SD of proportional residual error	0.036 (0.030 - 0.040)
Correlation (η_Kin, η_Kout)	0.87
Correlation (η_Kin, η_β)	-0.98
Correlation (η_Kout, η_β)	-0.95

CI: confidence intervals, obtained by bootstrap (n = 1000), SD: standard deviation, IIV: interindividual variability, CV: the apparent coefficient of variation of interindividual variability.

ISSN: 1750-1172