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Table 5 Parameter estimates of the population MCV model

From: Population pharmacokinetics and pharmacodynamics of hydroxyurea in sickle cell anemia patients, a basis for optimizing the dosing regimen

Parameters Typical values (95% CI) SD of IIV (95% CI) Interindividual CV
Kin (%/day) 3.71 (3.13 - 4.30) 0.191 (0.083 - 0.401) 19%
Kout (day-1) 0.042 (0.035 - 0.048) 0.186 (0.044 - 0.415) 19%
β (L. mg-1)1/γ 0.099 (0.064 - 0.135) 0.457 (0.336 - 0.599) 48%
γ (unitless) 0.19 (0.02 - 0.46)   
θΔHbF%(day-1) 1.22 (-0.07 - 2.21)   
SD of proportional residual error 0.036 (0.030 - 0.040)   
Correlation (ηKin, ηKout) 0.87   
Correlation (ηKin, ηβ) -0.98   
Correlation (ηKout, ηβ) -0.95   
  1. CI: confidence intervals, obtained by bootstrap (n = 1000), SD: standard deviation, IIV: interindividual variability, CV: the apparent coefficient of variation of interindividual variability.