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Table 3 Summary statistics of PD variables

From: Population pharmacokinetics and pharmacodynamics of hydroxyurea in sickle cell anemia patients, a basis for optimizing the dosing regimen

PD variables At baseline
Median (range)
Number of patients After 6 months of treatment
Median (range)
Number of patients
HbF% 6.3 (0.6 - 30.7) 65 15.7 (3.9 - 41.6) 46
HbF (g/dL) 0.48 (0.04 - 2.7) 63 1.59 (0.34 - 4.04) 46
Hemoglobin (g/dL) 8.8 (6.3 - 11.9) 73 9.6 (6.9 - 14.4) 55
MCV (fL) 90 (68 - 113) 74 111 (81 - 131) 55
MCH (pg) 30 (21 - 36) 73 37 (25 - 44) 55
PMN (109/L) 56 (25 - 80) 71 49 (26 - 86) 53
Platelets (109/L) 428 (122 - 995) 74 316 (109 - 528) 55
Bilirubin (μM) 43 (9 - 96) 75 30 (6 - 113) 53
LDH (UI/L) 355 (155 - 800) 73 317 (168 - 766) 52
Ferritin (μg/L) 346 (16 - 4500) 72 275 (14 - 2940) 52
AST (UI/L) 32 (17 - 79) 75 31 (12 - 81) 53
ALT (UI/L) 22 (7 - 84) 75 21 (7 - 83) 53
Creatinine (μM) 65 (38 - 142) 75 64 (35 - 137) 52
Urea (μM) 2.9 (1.2 - 13.3) 75 3.3 (1.5 - 9) 52