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Table 2 Parameter estimates of the population PK model

From: Population pharmacokinetics and pharmacodynamics of hydroxyurea in sickle cell anemia patients, a basis for optimizing the dosing regimen

Parameters Typical values (95% CI) Standard deviations of IIV (95% CI) Interindividual CV
Vc/F (L) (for a patient of 70 kg) 45.3 (38.9 - 50.5) 0.34 (0.23 - 0.46) 35%
Cl/F (L/h) (for a patient of 70 kg) 11.6 (10.4 - 12.9) 0.29 (0.22 - 0.40) 30%
ka (h-1) 3.29   
θka (h-1) () 3.02 (2.25 - 4.19) 1.34 (1.16 - 1.65) 224%
kcp (h-1) 0.027 (0.021 - 0.037) 0.57 (0.43 - 0.95) 62%
kpc (h-1) (fixed) 0.004 - -
SD of the additive component of the residual error (mg/L)    
- for densely sampled data 0.319 (0.197 - 0.492)   
- for sparsely sampled data 0.353 (0.257 - 0.522)   
SD of the proportional component of the residual error    
- for densely sampled data 0.12 (0.083 - 0.154)   
- for sparsely sampled data 0.435 (0.349 - 0.506)   
Correlation (ηVc, ηCl) 0.71   
Correlation (ηVc, ηkcp) -0.26   
Correlation (ηCL, ηkcp) 0.37   
  1. CI: confidence intervals, obtained by bootstrap (n = 1000), IIV: interindividual variability, CV: the apparent coefficient of variation of interindividual variability.