Table 2 Parameter estimates of the population PK model

V_c/F (L) (for a patient of 70 kg)

45.3 (38.9 - 50.5)

0.34 (0.23 - 0.46)

35%

Cl/F (L/h) (for a patient of 70 kg)

11.6 (10.4 - 12.9)

0.29 (0.22 - 0.40)

30%

k_a (h^-1)

3.29

θ_ka (h^-1) ()

3.02 (2.25 - 4.19)

1.34 (1.16 - 1.65)

224%

k_cp (h^-1)

0.027 (0.021 - 0.037)

0.57 (0.43 - 0.95)

62%

k_pc (h^-1) (fixed)

0.004

-

-

SD of the additive component of the residual error (mg/L)

- for densely sampled data

0.319 (0.197 - 0.492)

- for sparsely sampled data

0.353 (0.257 - 0.522)

SD of the proportional component of the residual error

- for densely sampled data

0.12 (0.083 - 0.154)

- for sparsely sampled data

0.435 (0.349 - 0.506)

Correlation (η_Vc, η_Cl)

0.71

Correlation (η_Vc, η_kcp)

-0.26

Correlation (η_CL, η_kcp)

0.37