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Table 2 Summary of effects of polyclonal and monoclonal antibodies on parameters measured in this study.

From: Respective implications of glutamate decarboxylase antibodies in stiff person syndrome and cerebellar ataxia

 

Glutamate levels

Glycerol turnover

Cerebello-cortical inhibition

Corticomotor response

F/M ratio

Enzyme inhibition

Epitope pattern

Ab SPS

Increase

No effect

No effect

No effect

Increase

Inhibition

Inhibition by: b78, b96.11

Ab CA

No effect

Reduction

Decrease

Impairment

Increase

No effect

Inhibition by: B78

Ab Ctrl

No effect

No effect

No effect

No effect

No effect

No effect

No effect

B96.11

Increase

No effect

Decrease

Impairment

Increase

No effect

Inhibition by: B96.11

B78

Strong increase

Reduction

Strong decrease

Strong impairment

Strong increase

Inhibition

Inhibition by: B78