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Table 2 Clinical characteristics and treatment

From: Epithelial thymic tumours in paediatric age: a report from the TREP project

N

Tumour type

Age (years)

Stage

Symptoms

Size (cm)

Local extent

Lymph nodes

Metastasis

Surgery

CT

RT (Gy)

Outcome/FU (m)

1

Thymoma B1

4.8

I

Cough

>5 e <10

no

no

no

Complete resection at diagnosis

No

No

1°CR/35.2

2

Thymoma B1

12.4

IVb

Dyspnoea, coma

   

Kidney, bilaterally

No

No

No

Died

3

Thymoma B1

11.4

I

Incidental (radiography for scoliosis)

4×2.5×2

no

no

no

Complete resection at diagnosis

No

No

1°CR/93.40

4

Thymoma AB

15

I

Chest pain, fever

16×8×14

no

no

no

Complete resection at diagnosis

No

No

1°CR/21.7

5

Lympho-epithelioma-like carcinoma

11.7

III

Chest pain, joint pain, fever, butterfly rash, digital clubbing

12×9×6

Lung, lymph node

Mediastinal

no

Incomplete resection at diagnosis

Ifo-VCR+ACT (1 cycle) CDDP+VP16 (2 cycles)

50

Died/12

6

Carcinoma with neuroendocrine differentiation

15.5

IVb

Shoulder pain

10×6×12

Sternum, pleural/pericardial effusion

Latero-cervical, mediastinal

Bone

Lymph node biopsy at diagnosis

CDDP+ VP16 (7 cycles)

Yes

Died/17

7

Poorly differentiated carcinoma

14.7

IVb

Fever, vomiting, weight loss, abdominal and chest pain

>5

Lung

Mediastinal

Bone

Lymph node biopsy at diagnosis

CDDP+5FU (1 cycle) CDDP+ADR+VCR+CPM (5 cycles)

45

Died/10

8

Poorly differentiated carcinoma

16.3

IVb

Cough, fever, fatigue, back pain

>5 e <10

no

Latero-cervical

Liver, bone

Lymph node biopsy at diagnosis

CDDP+CPM+ADR (4 cycle)

No

Died/7

9

Lympho-epithelioma-like carcinoma

12

IVa

Fatigue, weight loss, dyspnoea

10×10

Pleural nodes and effusion

Left hylar, mediastinal

no

Incomplete resection after chemotherapy

CDDP+5FU (4 cycles) CDDP (6 cycle)

54

Died/16

  1. IFO = Ifosfamide, VCR = Vincristine, ACT = Actinomycin, CDDP = Cisplatin, VP16 = Etoposide, 5FU = Fluorouracil, CPM = Cyclophosphamide, ADR = Adriamycin, CT = chemotherapy, RT = radiotherapy, FU = follow-up (months), 1°CR = first complete remission